A well made made joint, with modern glues, will out preform the soft woods. Such as, cedar, redwood ...ect, all the conifers. Knots are the weakest points. Cut out the knots that equal 1/4 or more of the dimension of the stock then try not to over think it. Remember that you are working with a natural product. Logical compromise from perfection will be necessary.
You can always clamp it in a vice and test the break strengths. It will make you confident in the process.